Object-oriented modeling of thoracic fluid balance to study cardiogenic pulmonary congestion in humans.

•The first biophysical computational model of fluid balance between pulmonary capillaries and lung interstitium.•The first approach of an object-oriented model for the lymphatic system.•The first comprehensive model to include the respiratory, the circulatory, and fluid exchange systems for an advanced description of cardiogenic congestion.•Its ability to demonstrate the effect of mechanical ventilation on extravascular fluid clearance.