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Excessive CD11c + Tbet + B cells promote aberrant T FH differentiation and affinity-based germinal center selection in lupus.

Proceedings of the National Academy of Sciences of the United States of America, no. 37 (2019): 18550-18560

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Excessive self-reactive and inadequate affinity-matured antigen-specific antibody responses have been reported to coexist in lupus, with elusive cellular and molecular mechanisms. Here, we report that the antigen-specific germinal center (GC) response-a process critical for antibody affinity maturation-is compromised in murine lupus model...更多

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作者
Wenqian Zhang
Wenqian Zhang
Huihui Zhang
Huihui Zhang
Shujun Liu
Shujun Liu
Fucan Xia
Fucan Xia
Zijian Kang
Zijian Kang
Yan Zhang
Yan Zhang
Yaoyang Liu
Yaoyang Liu
Hui Xiao
Hui Xiao
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