Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin

Tadato Ban,Takaya Ishihara,Hiroto Kohno,Shotaro Saita,Ayaka Ichimura,Katsumi Maenaka,Toshihiko Oka,Katsuyoshi Mihara,Naotada Ishihara

NATURE CELL BIOLOGY（2017）

引用 265|浏览10

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摘要

Ban et al. show that optic atrophy 1 (OPA1) and cardiolipin mediate mitochondrial fusion. In contrast, a homotypic trans -OPA1 interaction independent of cardiolipin mediates membrane tethering to form mitochondrial cristae.

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关键词

Mitochondria,Membrane fusion,Lipid signalling

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