Interleukin 1 beta and Matrix Metallopeptidase 3 Contribute to Development of EGFR-dependent Serrated Polyps in Mouse Cecum.
Gastroenterology(2019)
摘要
In studies of mice, we found that barrier breakdown and expression of inflammatory factors contribute to development of serrated polyps. Subsets of cecal PDGFRA-positive fibroblasts are activated by release of IL1B from myeloid cells during early stages of serrated polyp development. MMP3 produced by PDGFRA-positive fibroblasts is important for serrated polyp development. Our findings confirm the functions of previously identified serrated polyp-associated molecules, and indicate roles for immune and stromal cells in serrated polyp development.
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关键词
Neoplasm,Cytokine,Stroma,Barrier Breakdown
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