A Gaussian process-based definition reveals new and bona fide genetic interactions com-pared to a multiplicative model in the Gram-negative Escherichia coli

Ali Hosseinnia
Ali Hosseinnia
Sadhna Phanse
Sadhna Phanse
Sunyoung Kim
Sunyoung Kim
Khaled A Aly
Khaled A Aly

BIOINFORMATICS, pp. 880-889, 2019.

Cited by: 0|Views7
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Abstract:

Motivation: A digenic genetic interaction (GI) is observed when mutations in two genes within the same organism yield a phenotype that is different from the expected, given each mutation's individual effects. While multiplicative scoring is widely applied to define GIs, revealing underlying gene functions, it remains unclear if it is the ...More

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