I K1 Channel Agonist Zacopride Alleviates Cardiac Hypertrophy and Failure via Alterations in Calcium Dyshomeostasis and Electrical Remodeling in Rats

Qing-Hua Liu
Qing-Hua Liu
Xi Qiao
Xi Qiao
Jin Wang
Jin Wang
Li Zhang
Li Zhang
Xu-Wen Zhai
Xu-Wen Zhai
Xiao-Ze Ren
Xiao-Ze Ren
Yu Li
Yu Li
Xiao-Na Cao
Xiao-Na Cao

FRONTIERS IN PHARMACOLOGY, pp. 9292019.

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Abstract:

Intracellular Ca2+ overload, prolongation of the action potential duration (APD), and downregulation of inward rectifier potassium (I-K1) channel are hallmarks of electrical remodeling in cardiac hypertrophy and heart failure (HF). We hypothesized that enhancement of I-K1 currents is a compensation for I-K1 deficit and a novel modulation ...More

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