Serotonin and Serotonin Reuptake Inhibitors Alter Placental Aromatase.

•SRIs have a binding affinity for the substrate-binding pocket of CYP19 protein.•SRIs differentially alter aromatase activity in BeWo and primary villous trophoblast.•Primary villous trophoblasts are more sensitive to inhibition of aromatase activity by SRIs.•Serotonin and 5-HT2A agonist induce aromatase activity in primary villous trophoblast.