An immunoinformatics approach for design and validation of multi-subunit vaccine against Cryptosporidium parvum.
Immunobiology(2019)
摘要
•An immunoinformatics approach for design of multi-subunit vaccine against C. parvum.•Best screened BCL, TCL and HCL epitopes were interlinked by help of relevant linkers.•The 3D model of the protein was predicted and was docked with TLR2 and TLR4 receptors.•MD simulation was carried out to determine the binding stability of receptor-vaccine interaction.
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关键词
Immunoinformatics,Cryptosporidium parvum,Epitopes,Multi-subunit vaccine,In silico cloning,Molecular dynamics simulation
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