Neuroprotection and immunomodulation in the gut of parkinsonian mice with a plasmalogen precursor.
Brain Research(2019)
摘要
•DHA-containing PlsEtn (PPI-1011) restores PlsEtn levels in a Parkinson’s disease model.•PPI-1011 prevents the loss of enteric dopaminergic neurons against MPTP toxicity.•PPI-1011 reduces the infiltration of enteric macrophages after MPTP treatment.•Protective effect of PPI-1011 are observed for pre- and post-MPTP treatment.
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关键词
CNS,DA,DBH,DHA,ENS,GPR120,Iba-1,LB,MHCII,MPTP,PD,PlsEtn,TNF-α,TH
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