Quercetin inhibition of SREBPs and ChREBP expression results in reduced cholesterol and fatty acid synthesis in C6 glioma cells.

Fabrizio Damiano,Laura Giannotti,Gabriele V Gnoni,Luisa Siculella,Antonio Gnoni

The International Journal of Biochemistry & Cell Biology（2019）

引用 24|浏览15

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摘要

•Quercetin rapidly inhibits cholesterol and fatty acid synthesis in C6 glioma cells.•Quercetin reduces the activity of ACC1 and HMGCR.•Quercetin acts at transcriptional level by decreasing expression of SREBPs and ChREBP.

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关键词

3-Hydroxy-3-methyl-glutaryl-CoA reductase,Acetyl-CoA carboxylase 1,C6 glioma cells,Cholesterol and fatty acid synthesis,ChREBP and SREBPs,Quercetin

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