Elevation Of Mac-2 Binding Protein Glycosylation Isomer After Hepatectomy Is Associated With Post-Hepatectomy Liver Failure, Total Pringle Time, And Renal Dysfunction

Background Mac-2 binding protein glycosylation isomer (M2BPGi) is a novel serum glycomarker used to assess liver fibrosis. However, it has been reported that M2BPGi is likely to reflect other factors not limited to liver fibrosis. Methods We retrospectively analyzed 79 patients with liver tumors who underwent liver resection. M2BPGi was measured within 1 week before operation and almost 1 month after operation. We introduced a value termed the "Delta M2BPGi ratio" (=M2BPGi(after operation)/M2BPGi(before operation)), and analyzed factors that influenced the Delta M2BPGi ratio. Results The median value of the Delta M2BPGi ratio was 1.28 (range, 0.36-5.68). In 64 patients (81.0%), the cutoff index values of M2BPGi were elevated approximately 1 month after operation, especially in patients who experienced post-hepatectomy liver failure (PHLF). Multiple linear regression showed total Pringle time, PHLF grade >= B, and preoperative value of creatinine were significant predictors of the Delta M2BPGi ratio. The mean values of the Delta M2BPGi ratio were 1.37 +/- 0.07, 1.52 +/- 0.22, and 2.94 +/- 0.30 for PHLF grade 0, grade A, and grade B, respectively, resulting in statistically significant differences by the Kruskal-Wallis test (P = 0.022). Conclusions Total Pringle time, PHLF grade >= B, and preoperative creatinine significantly influenced the elevation of M2BPGi almost 1 month after liver resection. This study strongly affirms the previous suggestion that M2BPGi is likely to reflect other factors not limited to liver fibrosis.