Neue Einblicke in die Entstehung von komplexen Karyotypen bei Krebs

Cancer cells differ from healthy cells by massively altered genomes. This includes point mutations as well as chromosomal rearrangements and changes in chromosome numbers. Novel in vitro models mimic chromosomal aberrations and allow their systematic analysis. Here we present recent findings how changes in chromosome numbers and their structure alter physiology of human cells and instigate further genomic instability, thus recapitulating the processes that occur during tumorigenesis.