Sulfuric acid supported on silica gel: An efficient catalyst for silylation of hydroxyl groups with HMDS and their convenient deprotection under non-aqueous condition

A mild and efficient silylation of alcohols and phenols with hexamethyl-disilazane(HMDS) and convenient desilylation of the corresponding silyl ethers are achieved using a catalytic amount of H2SO4/SiO2 under non-aqueous condition. In this work chemoselective silylation of hydroxy compounds in the presence of thiols and amines is conducted.