Attenuation of frailty in older adults with mesenchymal stem cells

•Frailty is a syndrome characterized by exhaustion, weight loss, a feeling of slowing down, and low levels of activity.•Frailty is associated with chronic inflammation and depletion or impairment of endogenous precursor and stem cells.•Interventions such as nutritional supplementation, physical exercise have shown inconsistent and modest benefits.•Use of allogeneic mesenchymal stem cells (MSCs) is a novel approach that addresses the pathophysiology of the syndrome.•Clinical studies show that MSCs are safe and potentially efficacious, ameliorating signs and symptoms of frailty.