A convenient synthesis of 8-alkyl-2' (or 3')-azido (or amino)-2' (or 3')-deoxyadenosine as diverse synthetic precursors of cyclic adenosine diphosphate ribose (cADPR)

key nucleoside intermediates for the preparation of cyclic adenosine diphosphate ribose (cADPR, 1) analogues, 8-alkyl-2' (or 3')-azido(or amino)-adenosine derivatives (16-19) were successfully prepared by alkylating selectively protected adenosine derivatives (12, 13) via Pd(0) catalyzed cross-coupling reaction with tetraalkyltin reagents...More