Effect of Monocyte Seeding Density on Dendritic Cell Generation in an Automated Perfusion-Based Culture System
Biochemical Engineering Journal(2019)
摘要
•Monocyte seeding density affects phenotype of generated immature DCs.•Immature DC phenotype affects extent of T cell proliferation.•MicroDEN successfully generates functionally competent immature DCs.•MicroDEN immature DCs induce greater T cell proliferation than well plate DCs.•MicroDEN generates similar DC counts to well plates at highest MO seeding density.
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关键词
Monocyte seeding density,Dendritic cells,Dendritic cell functionality,T cell expansion,Perfusion,Automated cell culture
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