MON-211 KELCH LIKE FAMILY MEMBER 3 KNOCK-OUT AMELIORATES RENAL FIBROSIS IN UNILATERAL URETERAL OBSTRUCTION MICE.

D.E. Choi,K.W. Lee,K.R. Na,Y.K. Chang,Y. Ham,J.W. Jeon, H. Kim,J.Y. Jeong

Kidney International Reports（2019）

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摘要

KLHL3 kelch like family member 3 (KLHL3) regulate some electrolyte in kidney tubules. In human, the mutation of KLHL3 induce hypertension, characterized by pseudoaldosteronism (decreasing aldosterone). We evaluated whether the KLHL3 could be fair target of RAAS inhibition, resulting in inhibition of renal fibrosis in unilateral ureteral obstructed (UUO) mice

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关键词

unilateral ureteral obstruction mice,knock-out

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