Appetite change profiles in depression exhibit differential relationships between systemic inflammation and activity in reward and interoceptive neurocircuitry.

•Depression with increased appetite (MDD-A+) has been linked to systemic inflammation.•We explored how food hedonics in MDD relate to systemic inflammation (plasma CRP).•Striatum activity in all participants with MDD positively correlated with CRP.•OFC and anterior insula activity positively correlated with CRP in only MDD-A+.•Food hedonics in MDD appetite change profiles differentially relate to inflammation.