Fingolimod promotes angiogenesis and attenuates ischemic brain damage via modulating microglial polarization.

Ke Shang,Jia He,Jing Zou,Chuan Qin,Li Lin,Luo-Qi Zhou,Lin-Lin Yang,Long-Jun Wu,Wei Wang,Ke-Bin Zhan,Dai-Shi Tian

Brain Research（2020）

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摘要

•FTY720 had a long-term neuroprotection in photothrombotic ischemic stroke.•Neuroprotection of FTY720 in PT was partly mediated by microglial polarization.•Angiogenesis was indirectly enhanced via microglial polarization mediated by FTY720.

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关键词

Arg-1,BBB,BrdU,CNS,ECs,iNOS,IFN,LPS,OGD,PT,S1PR

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