Validation of NGS for mitochondrial DNA casework at the FBI Laboratory.

Michael D Brandhagen,Rebecca S Just,Jodi A Irwin

Forensic Science International: Genetics（2020）

引用 54|浏览3

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摘要

•Validation studies were performed in accordance with SWGDAM guidelines for NGS.•Results show the efficacy, accuracy, reproducibility and reliability of the assay.•Recovery of full CR data increased by 20-60x compared to current Sanger protocols.•Overall, the NGS assay simplifies and improves the efficiency of the mtDNA workflow.•The FBI Laboratory plans near-term implementation of NGS for all mtDNA casework.

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关键词

Next Generation Sequencing (NGS),Massively Parallel sequencing (MPS),mtDNA,Validation,Forensic Science,MiSeq,SWGDAM Guidelines

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