Preparation of a supersaturatable self-microemulsion as drug delivery system for ellagic acid and evaluation of its antioxidant activities
Journal of Drug Delivery Science and Technology(2019)
摘要
The objective of this study was to improve the solubility of ellagic acid using supersaturatable self-microemulsifying drug delivery system (S-SMEDDS). Ternary phase diagrams and central composite design were constructed to optimize the formulation of ellagic acid-loaded supersaturatable self-microemulsion. It was found that the optimal formulation was comprised of 10% ethyl oleate, 67.5% Tween 80, 22.5% polyethylene glycol 400, 0.5% polyvinylpyrrolidone K30 and 4 mg g−1 ellagic acid. The morphologies and particle size studies indicated that ellagic acid-loaded S-SMEDDS were spherical particles with a droplet size of about 40 nm. And the in vitro dissolution study showed that ellagic acid could dissolute from the S-SMEDDS within a short time and exhibited more rapid release from S-SMEDDS than from SMEDDS. What's more, the in vitro and in vivo antioxidant ability of ellagic acid-loaded S-SMEDDS were significantly higher than those of pure ellagic acid at the same concentration. In conclusion, supersaturatable self-microemulsion is a potential carrier for the ellagic acid.
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关键词
Ellagic acid,Supersaturatable self-microemulsion,Central composite design,Antioxidant activity
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