Diagnostic DNA Methylation Biomarkers for Renal Cell Carcinoma: A Systematic Review

Kim Lommen,Nathalie Vaes,Maureen J. Aarts,Joep G. van Roermund,Leo J. Schouten,Egbert Oosterwijk,Veerle Melotte,Vivianne C. Tjan-Heijnen,Manon van Engeland,Kim M. Smits

European Urology Oncology（2021）

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摘要

We reviewed whether DNA methylation biomarkers could be used to diagnose renal cell carcinoma. We conclude that due to limited evidence, and inadequate reporting and research methodology, none of these biomarkers are clinically useful and their further development is hampered.

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关键词

Biomarkers,Diagnosis,DNA methylation,Kidney cancer,Promoter CpG island methylation,Renal cell carcinoma

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