Ghrelin in Alzheimer’s disease: Pathologic roles and therapeutic implications

Seong Gak Jeon,Sang Bum Hong,Yunkwon Nam, Jungyeon Tae,Anji Yoo,Eun Ji Song, Kun Il Kim,Dongje Lee,Junyong Park,Sang Min Lee,Jin-il Kim,Minho Moon

Ageing Research Reviews（2019）

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摘要

•The role of ghrelin on the AD pathogenesis and symptoms.•Interventional role of ghrelin in AD-associated pathologies and symptoms.•Therapeutic potential of ghrelin as a target for AD-modifying strategy.

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关键词

AD,AChE,acyl-ghrelin,AMPK,apo,APP,ARC,Aβ,AβO,BBB,BDNF,CaMKII,CDK,CNS,DG,DRN,ERK,FACS,GABA,GHS-R,GHRP-6,GKO,GOAT,GPCR,GSK,i.c.v,IGF-1,IL,LPS,LRP,LTD,LTP,MACRO,MAPK,MCI,MPTP,MSG,NSC,NFT,NMDA,p75NT,PD,PI3-K,PLC,RAGE,ROS,SGZ,UCP2,α2M

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