Efficacy and Safety of Combination Pharmacotherapy for Patients with Overactive Bladder: A Rapid Evidence Assessment.

A review of studies reporting the efficacy/safety of two antimuscarinics or a β3-adrenoreceptor agonist plus an antimuscarinic for overactive bladder symptoms found that mirabegron plus solifenacin was effective and well tolerated. Limited data for dual antimuscarinic therapy suggested benefits for moderate-to-severe symptoms.