Bismuth Trichloride-Catalyzed Oxy-Michael Addition Of Water And Alcohol To Alpha,Beta-Unsaturated Ketones
CHINESE CHEMICAL LETTERS(2020)
摘要
An efficient method was developed for the conjugate addition of water to various alpha,beta-unsaturated ketones by using bismuth(111) chloride as a catalyst. The reactions proceeded smoothly in the presence of a catalytic amount of BiCl3 (20 mol%) in aqueous media to furnish a variety of synthetically useful beta-hydroxyl ketones in moderate to good yields. Apart from water molecule, various alcohols could also be employed as nucleophiles to react with alpha,beta-unsaturated ketones, leading to beta-alkoxyl ketones in modest to high yields. In addition, the mild reaction conditions also entailed the conjugate addition reactions to proceed with the tolerance to a range of functional groups. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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关键词
Bismuth trichloride,Water,beta-Hydroxyl carbonyl compound,Michael addition,Functional group tolerance
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