Interaction of Naringin and Naringenin with DPPC Monolayer at the Air-Water Interface

The interaction of naringin and naringenin with DPPC monolayer at the air-water interface was investigated by coarse grained molecular dynamics and grazing incidence X-ray off-specular scattering (GIXOS). By molecular dynamics, we found that the DPPC monolayer is not disturbed by the addition of flavonoids at the surface tension of 28 mN m(-1). The flavonoids are located in the region of phospholipid polar heads. The GIXOS experiments show that the addition of flavonoids does not change the film thickness at the surface tension of 28 mN m-1, which is in excellent agreement with molecular dynamics simulation. Our very preliminary study indicates that DPPC may be used as a delivery system for the administration of naringenin and naringin to the lung.