Developing Trojan horses to Induce, Diagnose and Suppress Alzheimer’s Pathology

Pharmacological Research(2019)

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摘要
Monoclonal antibodies for receptors on blood-brain barrier can act as molecular Trojan horses to transport the fused novel classes of re-engineered AD causative agents, diagnostic probes, or multiple function neurovascular medicines across the BBB via receptor-mediated transport to cause, diagnose, or improve the AD phenotype, respectively.
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关键词
AD,,CAA,BBB,IGF-1,GLUT1,LRP1,RAGE,APC,RMT,MAb,QDs,CMT,GDNF,TfR,IgGs,EPCR,VEGF
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