Changes in vascular permeability in the spinal cord contribute to chemotherapy-induced neuropathic pain.

Karli Montague-Cardoso,Thomas Pitcher,Kim Chisolm, Giorgia Salera,Erik Lindstrom,Ellen Hewitt,Egle Solito,Marzia Malcangio

Brain, Behavior, and Immunity（2020）

引用 27|浏览8

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摘要

•Vincristine (VCR) induced nociception can be dose-limiting.•VCR increases permeability of the blood-spinal cord barrier.•Increased permeability results in infiltration of monocytes into the spinal cord.•Infiltrating monocytes express the pronociceptive enzyme Cathepsin S (CatS).•A centrally-penetrant CatS antagonist reduces VCR-induced nociception.

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关键词

Chemotherapy-induced neuropathic pain,Vincristine,Monocytes,Permeability,Blood-spinal cord barrier,Endothelium,Infiltration,Tight Junctions,Cathepsin S

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