Permeability and transport mechanism of trihexyphenidyl hydrochloride in Caco-2 cell monolayer model with a validated UPLC-MS/MS method.

Chengcan Lu,Kejia Fu,Kangna Cao,Jiali Wei,Jing Zhou,Di Zhao,Ning Li,Yang Lu,Xijing Chen,Yongjie Zhang

Journal of Pharmaceutical and Biomedical Analysis（2020）

引用 12|浏览57

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摘要

•A permeability model of Caco-2 cells monolayer was established and validated.•A rapid and sensitive UPLC-MS/MS method was developed for determining TH in D-hanks.•TH is a highly permeable drug and the transport mechanism is passive diffusion.

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关键词

QC,QCL,QCM,QCH,ULOQ,BLQ,AP,BL

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