Immobilization of the glucose isomerase from Caldicoprobacter algeriensis on Sepabeads EC-HA and its efficient application in continuous High Fructose Syrup production using packed bed reactor

•The GICA was immobilized onto amino supports with very high recovery yield.•The adsorbed GICA showed an improvement on its thermo-stability.•An excellent operational stability in batch reactor cycles was observed at 85 °C.•A continuous packed bed reactor system was established for HFS production at 70 °C.