The Synergistic Effect of Chlorotoxin-Mapoe in Boosting Drug-Loaded Liposomes Across the BBB

Beatrice Formicola,Roberta Dal Magro,Carlos V. Montefusco-Pereira,Claus-Michael Lehr,Marcus Koch,Laura Russo,Gianvito Grasso,Marco A. Deriu,Andrea Danani,Sandrine Bourdoulous,Francesca Re

Journal of nanobiotechnology（2019）

引用 19|浏览19

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摘要

We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood–brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes.

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关键词

Nanoparticles,Liposomes,Brain,Blood–brain barrier,Drug delivery,Doxorubicin,Chlorotoxin,Glioblastoma

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