Antibody response against HERV-W in patients with MOG-IgG associated disorders, multiple sclerosis and NMOSD.

Giannina Arru,Elia Sechi,Sara Mariotto,Ignazio R Zarbo,Sergio Ferrari,Alberto Gajofatto,Salvatore Monaco,Giovanni A Deiana,Marco Bo,Leonardo A Sechi,Gian Pietro Sechi

Journal of Neuroimmunology（2020）

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摘要

Increased expression of the retroviruses of HERV-W family has been linked to multiple sclerosis (MS) pathophysiology; nothing is known at the moment about MOG-IgG associated disorders. We compared antibody response against HERV-W peptides among patients with MOG-IgG associated disorders, multiple sclerosis (MS) and aquaporin-4 (AQP4)-IgG positive neuromyelitis optica spectrum disorder (NMOSD). A total of 102 serum samples were retrospectively analyzed.

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关键词

MS,Myelin oligodendrocyte glycoprotein,Neuromyelitis optica spectrum disorder,Autoimmunity,Human endogenous retroviruses

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