Discovery of a potent small molecule inhibiting Huntington's disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein

Eshan Khan
Eshan Khan
Subodh Kumar Mishra
Subodh Kumar Mishra
Ribhav Mishra
Ribhav Mishra

Scientific reports, pp. 168722019.

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Abstract:

CAG repeats RNA causes various fatal neurodegenerative diseases exemplified by Huntington's disease (HD) and several spinocerebellar ataxias (SCAs). Although there are differences in the pathogenic mechanisms, these diseases share the common cause, i.e., expansion of CAG repeats. The shared cause of these diseases raises the possibility f...More

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