Guidelines for the design of (optimal) isothermal inactivation experiments.
Food Research International(2019)
摘要
•We develop a methodology for OED of isothermal inactivation.•The OED considers a two-dimensional design space and the detection limit.•The optimal designs calculate more precise parameter than uniform designs.•An intermediate reference temperature increases the precision of parameter estimates.•We provide guidelines that combine results from OED and experimental limitations.
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关键词
Parameter estimation,Predictive microbiology,Pasteurization,Microbial kinetics,Robust statistics
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