Conserved HA-peptides expressed along with flagellin in Trichoplusia ni larvae protects chicken against intranasal H7N1 HPAIV challenge.

Marta Sisteré-Oró, Susana Martínez-Pulgarín,David Solanes,Veljko Veljkovic,Sergi López-Serrano,Lorena Córdoba,Ivan Cordón,José M Escribano,Ayub Darji

Vaccine（2020）

引用 4|浏览21

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摘要

•Extracts of T.ni larvae expressing flagellin-NG34/CS17 protected chickens against a heterologous H7N1 IV strain.•Flagellin-NG34/CS17 vaccinated chickens saved from flu-like clinical signs.•Flagellin-NG34/CS17 vaccinated chickens limited oropharyngeal and cloacal shedding.•Flagellin-NG34/CS17 induced an increase in IgM and improved IgY response.

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关键词

Avian influenza,H7 subtype,Baculovirus,Pandemic flu,Influenza vaccine,Conserved peptides,Flagellin,Cross-protection

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