ASL Metabolically Regulates Tyrosine Hydroxylase in the Nucleus Locus Coeruleus
Cell Reports, pp. 2144-2153.e7, 2019.
Patients with germline mutations in the urea-cycle enzyme argininosuccinate lyase (ASL) are at risk for developing neurobehavioral and cognitive deficits. We find that ASL is prominently expressed in the nucleus locus coeruleus (LC), the central source of norepinephrine. Using natural history data, we show that individuals with ASL defici...More
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