ASL Metabolically Regulates Tyrosine Hydroxylase in the Nucleus Locus Coeruleus

Shaul Lerner
Shaul Lerner
Elmira Anderzhanova
Elmira Anderzhanova
Sima Verbitsky
Sima Verbitsky
Yuri Kuznetsov
Yuri Kuznetsov
Tevie Mehlman
Tevie Mehlman
Ram Mazkereth
Ram Mazkereth
Robert McCarter
Robert McCarter

Cell Reports, pp. 2144-2153.e7, 2019.

Cited by: 0|Views3
WOS

Abstract:

Patients with germline mutations in the urea-cycle enzyme argininosuccinate lyase (ASL) are at risk for developing neurobehavioral and cognitive deficits. We find that ASL is prominently expressed in the nucleus locus coeruleus (LC), the central source of norepinephrine. Using natural history data, we show that individuals with ASL defici...More

Code:

Data:

Your rating :
0

 

Tags
Comments