A Stapled Chromogranin A-derived Peptide is a Potent Dual Ligand for Integrins Αvβ6 and Αvβ8.

Francesca Nardelli,Michela Ghitti,Giacomo Quilici,Alessandro Gori,Qingqiong Luo,Andrea Berardi,Angelina Sacchi,Matteo Monieri,Greta Bergamaschi,Wolfgang Bermel,Fuxiang Chen,Angelo Corti,Flavio Curnis,Giovanna Musco

Chemical communications（2019）

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摘要

Combining 2D STD-NMR, computation, biochemical assays and click-chemistry, we have identified a chromogranin-A derived compound (5) that has high affinity and bi-selectivity for αvβ6 and αvβ8 integrins and is stable in microsomal preparations. 5 is suitable for nanoparticle functionalization and delivery to cancer cells, holding promise for diagnostic and/or therapeutic applications.

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