High Levels Of Hematopoietic Progenitors In The Fetal Lung Enable Induction Of Immune Tolerance And Co-Transplantation Of Epithelial Progenitors For Repair Of Lung Injury Across Mhc Barriers
BLOOD(2016)
摘要
Lung diseases are the second leading cause of death worldwide. There is a growing understanding that lung stem cells, rather than being distributed throughout the tissue, are concentrated in specialized niches. Thus, in our previous study we demonstrated that in analogy to bone marrow (BM) transplantation, lung progenitors could navigate through the blood to their appropriate niches, provided that the niches were cleared of endogenous cell populations (Nature Medicine 2015). Lung injury was induced by Naphthalene, and lung progenitors of all lineages were further depleted by 6GY total body irradiation (TBI) 48 hrs after Naphthalene exposure; at this time, endogenous lung progenitors proliferated extensively.
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