Cross-Platform Assessment Of Genomic Imbalance In Diffuse Large B-Cell Lymphoma Identifies Novel Candidate Loci And Genes With Prognostic Value And Roles In Lymphomagenesis

Diffuse large B-cell lymphomas (DLBCL) display marked clinical, pathologic, and genetic heterogeneity. With current frontline immunotherapy (RCHOP), only about 40% of patients are cured, with most relapses occurring within the first 2-3 years. Patients are currently risk-stratified based primarily on clinical features where the inclusion of molecular biomarkers into risk assessment could impact the potential to identify those patients most likely to have refractory disease or have an early relapse. Various cytogenomic studies have revealed the prognostic significance of genomic gain/loss in DLBCL, but their lack of utility and reproducibility across datasets can be attributed to not only different patient populations, but also the use of disparate platforms and analytical methods. The goal of the present study was to use a common analytical approach across different clinical datasets, to identify genomic loci with robust prognostic value in DLBCL.