Ex Vivo Activity Profile Of The Cd123xcd3 Duobody (R) Antibody Jnj-63709178 Against Primary Acute Myeloid Leukemia Bone Marrow Samples

Background/Aims:Acute myeloid leukemia (AML) is a hematologic malignancy that affects the normal production of neutrophils, red blood cells, and platelets. CD123 (IL-3 receptor alpha) is over-expressed on AML stem cells and blasts, compared with normal hematopoietic progenitor and stem cells, and represents a promising target for the development of antibody-based AML therapies (Jordan et al., Leukemia 2000;14:1777-1784).