Clinical and epidemiological characteristics of Coxsackievirus A6- and Enterovirus 71-associated clinical stage 2 and 3 severe hand, foot, and mouth disease in Guangxi, Southern China, 2017

•A total of 2350 severe HFMD cases with mild neurological symptoms were dividing into clinical stage 2 and stage 3.•The dominated pathogens for HFMD clinical stage 2 and 3 were CV-A6 and EV-A71, respectively.•Clinical symptoms preference existed among CV-A6, EV-A71, and CV-A10.