Clonal Trajectories in Persons with Acute Myeloid Leukemia and Normal Cytogenetics Relapsing after Intensive Chemotherapy and after Allotransplants. Does Pretransplant Conditioning Contribute to Mutation Topography?

Background One-half of persons with acute myeloid leukaemia (AML) have normal cytogenetics at diagnosis and a good prognosis. However, some relapse. Whether the clonal trajectory in these persons is like that of persons with unfavorable cytogenetics at diagnosis who relapse is unknown.