The influence of posttraumatic stress disorder and recurrent major depression on risk-taking propensity following trauma script exposure among patients with substance use disorders.

•The co-occurrence of PTSD and SUDs is associated with greater risk-taking behavior.•Recurrent major depression (MDD) may moderate this association.•Risk-taking assessed after a neutral and trauma script.•PTSD-MDD associated with lower risk-taking post-trauma script than PTSD alone.•PTSD-MDD had lesser risk-taking from neutral to trauma script than PTSD alone.•Assessing MDD may identify PTSD patients at greater/lesser risk for risky behaviors.