Bone marrow-derived mesenchymal stem cells-secreted exosomal microRNA-192-5p delays inflammatory response in rheumatoid arthritis.
International Immunopharmacology(2020)
摘要
•miR-192-5p is demonstrated as a downregulated miRNA in rheumatoid arthritis.•miR-192-5p targets and negatively regulates RAC2 in rheumatoid arthritis.•BMSCs-derived exosomes contain more abundant miR-192-5p expression than BMSCs.•miR-192-5p-overexpresed exosomes attenuates severity of rheumatoid arthritis in rats.•miR-192-5p-modified BMSCs may be beneficial for the treatment of RA.
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关键词
Rheumatoid arthritis,microRNA-192-5p,Bone marrow-derived mesenchymal stem cells,Exosomes,RAC2
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