Effects of lentivirus-mediated CCR3 RNA interference on the function of mast cells of allergic rhinitis in mice.

•A murine model of allergic rhinitis inducing by ovalbumin is constructed.•Administer lentiviral shRNA targeting CCR3 gene into the CCR3shRNA treated group.•The bone marrow, peripheral blood, nasal mucosa of mice are collected and assessed.•Explore the effect of CCR3-silencing on function of mast cells in AR mice in vivo.•CCR3shRNA downgrade the CCR3 gene in bone marrow, peripheral blood and nasal mucosa.•Inhibition of CCR3 gene expression can alleviate the inflammation of allergic rhinitis.