TRPM2 ion channel is involved in the aggravation of cognitive impairment and down regulation of epilepsy threshold in pentylenetetrazole-induced kindling mice.

Qianqian Zheng,Tao Zhu,Hui Hu,Yisha Zhao,Yingchao Ying,Xiaoying Luo,Yinjie Ling, Zhiyue Chen, Haoran Ji,Peifang Jiang

Brain Research Bulletin（2020）

引用 17|浏览7

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摘要

•Knockout of TRPM2 has a protective effect on epilepsy.•Knockout of TRPM2 can improve spatial memory deficits in epilepsy.•PARP1/BNIP3/AIF/Endo G signaling pathway may play an important role in epilepsy.

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关键词

AD,ADPR,AIF,Aβ,BNIP3,Caspase,cADPR,DG,ECL,Endo G,KO,PARP1,PARPs,PARG,PCR,PTZ,ROS,RT-PCR,TRPM2

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