Metabolism and urinary excretion kinetics of di(2-ethylhexyl) adipate (DEHA) in four human volunteers after a single oral dose.

Toxicology Letters(2020)

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摘要
•Human urinary excretion kinetics of di(2-ethylhexyl) adipate (DEHA) after oral dose.•New specific DEHA metabolite: mono-5-carboxy-2-ethylpentyl adipate (5cx-MEPA).•Urinary excretion fractions (FUE) for three specific DEHA metabolites.•Calculation of metabolite-based daily DEHA intakes for pilot populations.•Highest FUE and detection rates for 5cx-MEPA.
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关键词
DEHA,5OH-MEHA,5oxo-MEHA,5cx-MEPA,AA,DEHP,EHS,DEHTP,DPHP,DINCH,FUE,DI
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