Simultaneous determination of illegal drug substances in dietary supplements for gout and osteoporosis using ultra-performance liquid chromatography and liquid chromatography-quadrupole-time-of-flight mass spectrometry.

•A UPLC-PDA-based analytical method was developed for anti-gout and anti-osteoporosis drug substances.•The validation results showed a rapid process, high sensitivity, good accuracy and precision in the qualitative and quantitative analysis.•The application for this method to real samples, revealed that 16 samples were adulterated with dexamethasone.