MUC13 promotes intrahepatic cholangiocarcinoma progression via EGFR/PI3K/AKT pathways.

Tiemin Pei,Fanzheng Meng,Peng Xiao,Jihua Han,Ruipeng Song,Yaliang Lan,Yan Wang,Junlin Xue,Qingfu Lang,Zhefeng He,Jian Li,Zihao Guo, Guoxing Liu,Boshi Sun,Ming Zhao,Qinghui Meng,Desen Liang,Lianxin Liu

Journal of Hepatology（2020）

引用 57|浏览17

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摘要

•Mucin 13 is overexpressed and predicts poor survival among patients with intrahepatic cholangiocarcinoma.•Mucin 13 promotes intrahepatic cholangiocarcinoma progression by activating the EGFR/PI3K/AKT signaling pathway.•Mucin 13 is upregulated by hypermethylation-induced miR-212-3p downregulation in intrahepatic cholangiocarcinoma.

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关键词

Mucins,Liver cancer,Prognostic factor,miR-212-3p,Mouse,iCCA,Kinase

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