Interleukin-17 acts in the hypothalamus reducing food intake.

Guilherme Nogueira,Carina Solon,Rodrigo S Carraro,Daiane F Engel,Albina F Ramalho,Davi Sidarta-Oliveira,Rodrigo S Gaspar,Bruna Bombassaro,Ana C Vasques,Bruno Geloneze,Marco A Vinolo,Jose Donato Junior,Licio A Velloso

Brain, Behavior, and Immunity（2020）

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摘要

•Interleukin-17 is produced in the intestine in response to food intake.•Interleukin-17 receptor A, but not interleukin-17, is expressed in hypothalamic neurons.•Systemic and intracerebroventricular injection of interleukin-17 reduce caloric intake.•Interleukin-17 increases the expression of POMC in the hypothalamus.

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关键词

Hormone,Neurotransmitter,Brain,Food,Inflammation,Obesity

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